Biological Aging and Health Optimization


Biological aging and health optimization measures

LONGEVITY & HEALTHSPAN SPECIALIST

We don’t all age at the same rate: We all know that friend who looks 40 at 18 and the friend whose’s mom could be their sister. Similarly, our body parts don’t always age at the same rate as each other. Our skin may be much older than we are, or our liver might be 80 even though we a’re 30. Frankly, we may look great on the outside but be very ill on the inside.

Everest Health’s extended physical exam estimates the biological age of our red blood cells, white blood cells, kidneys, liver, thyroid, as well as phenotypic age. It also uses optimized ranges (versus standardized “normal” lab ranges) that are based on, the values of the world’s healthiest people with the lowest mortality/morbidity rate and at the most robust defenses against disease. These updated ranges have been developed as part of the Methuselah Protocol™, which is exclusive to clients of Everest Health.

This is important when optimizing health, because you want to review your lab results looking for measures that reflect “best health” outcomes, not simply what is average.

In addition to the recommended lab testing for the Protocol, we also offer a wide range of additional tests for the patient who wants to know as much as possible. We work with our patients in selecting the tests that provide the most meaningful data. We have also assessed many of the commercially available lab tests that correlate to health optimization and longevity, working on behalf of our patients to secure discounts for these additional services.

Frequently Asked Questions

LONGEVITY & HEALTHSPAN SPECIALIST
How is biological aging calculated?

Biological age is estimated through methods like DNA methylation analysis, telomere length measurement, and assessing inflammatory and metabolic markers. Physical function tests, imaging, and functional assessments also play a role. Machine learning models can predict biological age. These methods provide estimates of overall health and aging, rather than precise measurements, and are mostly used in research settings.

How often should you test your biological age?

Our patients undergo repeat examinations and screenings generally every 6 months to get the most accurate results possible. This allows us to curate a plan based on your current health status. The frequency of testing biological age depends on individual health goals and risk factors. For most people, testing every 1-2 years is sufficient to monitor changes over time. Those with specific health concerns or undergoing interventions aimed at slowing aging may benefit from more frequent testing, such as every 6 months.

Why is measuring your biological age important?

Measuring biological age is important because it provides a more accurate reflection of a person's health and aging status compared to chronological age. It can help identify individuals who may be at higher risk of age-related diseases or early mortality, even if they are chronologically young. By monitoring biological age, individuals and healthcare providers can track the effectiveness of interventions aimed at slowing aging and improving healthspan. This information guides personalized healthcare decisions and lifestyle choices to promote healthy aging.

What biomarkers are tested?

Several biomarkers are commonly tested to estimate biological age. These biomarkers reflect various aspects of health and aging at the cellular and molecular levels. Some of the key biomarkers include:

DNA Methylation: Patterns of DNA methylation change with age, and specific sites on the genome can be used to estimate biological age.

Telomere Length: Telomeres are protective caps at the end of chromosomes that shorten with each cell division and are considered a marker of cellular aging.

Inflammatory Markers: Chronic inflammation is associated with aging and age-related diseases. Biomarkers such as C-reactive protein (CRP) and interleukin-6 (IL-6) are often measured.

Metabolic Markers: Levels of cholesterol, glucose, insulin, and other metabolic markers can provide insights into metabolic health, which is closely linked to aging.

Physical Function Tests: Assessments of grip strength, walking speed, and other physical functions can indicate overall health and functional decline associated with aging.

Imaging Biomarkers: MRI and CT scans can reveal structural changes in the brain and other organs that occur with aging.

Cardiopulmonary Fitness: Measures of cardiovascular and pulmonary function, such as VO2 max, can reflect overall fitness and health status.

Cognitive Function Tests: Assessments of memory, processing speed, and other cognitive functions can indicate brain health and aging-related changes.

Epigenetic Clocks: These are mathematical models that use DNA methylation patterns to estimate biological age.

Hormone Levels: Levels of hormones such as testosterone, estrogen, and DHEA-S can change with age and impact overall health and vitality.

By analyzing these biomarkers collectively, researchers and healthcare providers can estimate an individual's biological age and assess their overall health and risk of age-related diseases.

Our proactive approach helps us create a personalized care plan to help you reduce the risk of serious health conditions. Our skilled coaching sessions offer an additional layer of support, encouragement, and accountability to make these lifestyle changes easy.

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